Production of monocyte chemoattractant protein 1 in tuberculosis patients.

نویسندگان

  • Y Lin
  • J Gong
  • M Zhang
  • W Xue
  • P F Barnes
چکیده

To investigate the role of monocyte chemoattractant protein 1 (MCP-1) in the immune response to Mycobacterium tuberculosis, we studied MCP-1 production in tuberculosis patients. CD14+ blood monocytes from tuberculosis patients spontaneously expressed higher levels of MCP-1 mRNA and protein than CD14+ monocytes from healthy tuberculin reactors. MCP-1 production in lymph nodes from tuberculosis patients was also markedly increased. These findings suggest that MCP-1 can contribute to the antimycobacterial inflammatory response by attracting monocytes and T lymphocytes.

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عنوان ژورنال:
  • Infection and immunity

دوره 66 5  شماره 

صفحات  -

تاریخ انتشار 1998